Exercise and Insulin Resistance Article uri icon

abstract

  • There is a general perception that increased physical activity will improve glucose homeostasis in all individuals.While this is an attractive concept, this conclusion may be overly simplistic and even misleading. The topic wasreviewed extensively over 30 years ago and it was concluded that acute exercise enhances glucose uptake.However, in some cases the chronic influence of interventions utilizing exercise may have little effect on glucosemetabolism. Moreover, insulin resistance often returns to near baseline levels within a couple of days followingcessation of the exercise bout; leaving the overall effectiveness of the intervention in question. Since improvingglucose homeostasis should be the focal endpoint of any intervention designed to mitigate the overwhelming degreeof insulin resistance in individuals at risk for metabolic disease, it is essential to evaluate the key components of a successful approach.